Hanley Christopher S, Simmons Heather A, Wallace Roberta S, Clyde Victoria L
Milwaukee County Zoo, Milwaukee, Wisconsin 53226, USA.
J Zoo Wildl Med. 2006 Dec;37(4):553-7. doi: 10.1638/06-036.1.
A 32.5-year-old female hybrid orangutan (Pongo pygmaeus) developed hind-limb stiffness that progressed to tetraparesis over 2 wk. Repeated diagnostic evaluations, including serial magnetic resonance imaging of the central nervous system, revealed nonspecific lesions involving both the deep white and gray matter with an intact blood-brain barrier. Multiple empirical treatments failed to produce improvement and the animal was humanely euthanized. Histology of a granuloma in the ileum contained a nematode parasite, most consistent with Baylisascaris procyonis. Additionally, neuropil vacuolization, rarefaction, astrocytic scarring, and an eosinophilic granuloma and lymphoeosinophilic perivascular cuffing in the brain were suggestive of nematode migration. These findings confirm the presence of visceral larval migrans and support the presence of neural larval migrans. This case report of Baylisascaris procyonis confirms the presentation for the first time in an ape and documents the difficulty in antemortem diagnosis of neural larval migrans.
一只32.5岁的雌性杂交猩猩（婆罗洲猩猩）出现后肢僵硬，在2周内进展为四肢轻瘫。反复的诊断评估，包括中枢神经系统的系列磁共振成像，显示涉及深部白质和灰质的非特异性病变，血脑屏障完整。多种经验性治疗均未改善，该动物被实施安乐死。回肠肉芽肿的组织学检查发现一种线虫寄生虫，最符合浣熊贝蛔虫。此外，大脑中的神经纤维空泡化、稀疏、星形细胞瘢痕形成以及嗜酸性肉芽肿和嗜酸性血管周围套袖提示线虫迁移。这些发现证实了内脏幼虫移行症的存在，并支持神经幼虫移行症的存在。这例浣熊贝蛔虫病例报告首次证实了在猿类中的表现，并记录了神经幼虫移行症生前诊断的困难。
