Bedoya Gabriel, García Jenny, Montoya Patricia, Rojas Winston, Amézquita Maria Eugenia, Soto Iván, López Maria Cecilia, Ospina-Duque Jorge, Ruiz-Linares Andrés
Grupo de Genética Molecular (GENMOL), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Biomedica. 2006 Dec;26(4):538-45.
Surname frequency (isonymy) is used as a marker of paternal lineage and is used to characterize human population structure. Principles of isonymy were used to determine the genetic structure, migration rates, ancestry relations and origins of populations. This analysis was applied to two historically related local populations which currently are considered to be genetically isolated.
The genetic relationships and influence zones of the Aranzazu and Marinilla populations were assessed by means of surname frequency analysis.
Data originated from database with the title "System of Identification of Beneficiaries of the Social Programs" database or Sisben. Population parameters such as a priori kinship (phi(ii)), population homogeneity with B and C estimators, and Cavalli-Sforza's genetic distance were calculated for (a) three towns of Marinilla and its influence zone and (b) Aranzazu. The Rionegro population served as an external, comparison population.
The Aranzazu and Marinilla populations showed the higher homogeneity (B value between 0.25 and 0.5) in contrast with Rionegro (B = 0.159), as well as greater a priori kinship values (4), between 0.003 and 0.010). The lowest distances were found between Marinilla and Aranzazu.
Aranzazu is a population with characteristics similar to those of Marinilla and its influence zone. The close similarity of genetic characteristics for these populations is due probably to a founder effect. Furthermore, the genetic similarity predicts that genetic diseases will have the same etiology in both populations and provides optimum conditions for gene mapping studies.
姓氏频率（同姓率）被用作父系血统的标志，并用于描述人类种群结构。同姓率原理被用于确定种群的遗传结构、迁移率、祖先关系和起源。该分析应用于两个历史相关的当地种群，目前它们被认为在基因上是隔离的。
通过姓氏频率分析评估阿兰萨祖和马里尼利亚种群的遗传关系和影响区域。
数据源自名为“社会项目受益者识别系统”数据库或Sisben。计算了以下各项的种群参数，如先验亲缘关系（phi(ii)）、使用B和C估计器的种群同质性以及卡瓦利 - 斯福扎遗传距离：(a) 马里尼利亚的三个城镇及其影响区域，以及 (b) 阿兰萨祖。里奥内格罗种群作为外部对照种群。
与里奥内格罗（B = 0.159）相比，阿兰萨祖和马里尼利亚种群显示出更高的同质性（B值在0.25至0.5之间），以及更大的先验亲缘关系值（4），在0.003至0.010之间。马里尼利亚和阿兰萨祖之间的距离最短。
阿兰萨祖是一个具有与马里尼利亚及其影响区域相似特征的种群。这些种群遗传特征的密切相似性可能归因于奠基者效应。此外，遗传相似性预测这两个种群的遗传疾病将具有相同的病因，并为基因定位研究提供了最佳条件。
