Grasser Klaus D, Launholt Dorte, Grasser Marion
Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK-9000 Aalborg, Denmark.
Biochim Biophys Acta. 2007 May-Jun;1769(5-6):346-57. doi: 10.1016/j.bbaexp.2006.12.004. Epub 2007 Jan 8.
In plants, the chromosomal high mobility group (HMG) proteins of the HMGB family typically contain a central HMG-box DNA-binding domain that is flanked by a basic N-terminal and an acidic C-terminal domain. The HMGB proteins are abundant and highly mobile proteins in the cell nucleus that influence chromatin structure and enhance the accessibility of binding sites to regulatory factors. Due to their remarkable DNA bending activity, HMGB proteins can increase the structural flexibility of DNA, promoting the assembly of nucleoprotein complexes that control DNA-dependent processes including transcription. Therefore, members of the HMGB family act as versatile modulators of chromatin function.
在植物中，HMGB家族的染色体高迁移率族（HMG）蛋白通常包含一个中央HMG盒DNA结合结构域，其两侧分别是碱性的N端和酸性的C端结构域。HMGB蛋白是细胞核中丰富且高度可移动的蛋白质，它们影响染色质结构，并增强结合位点对调控因子的可及性。由于其显著的DNA弯曲活性，HMGB蛋白可增加DNA的结构灵活性，促进控制包括转录在内的DNA依赖性过程的核蛋白复合物的组装。因此，HMGB家族成员充当染色质功能的多功能调节剂。
