Healy Claire, Abuzakouk Mohamed, Feighery Conleth, Flint Stephen
Department of Oral and Maxillofacial Surgery, Oral Medicine and Oral Pathology, Dublin Dental School and Hospital, Trinity College Dublin, Dublin, Ireland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May;103(5):e29-32. doi: 10.1016/j.tripleo.2006.11.015. Epub 2007 Feb 21.
This paper describes a middle-aged patient who developed repeated episodes of swelling of the orofacial tissues after dental treatment. On investigation, C1 inhibitor, C1q, C2, and C4 levels were all markedly reduced, and a diagnosis of acquired C1 inhibitor deficiency was made. The patient had been diagnosed with non-Hodgkin's lymphoma (NHL) 2 years previously and had undergone a successful course of chemotherapy. The development of her episodes of angioedema prompted thorough reinvestigation and a recurrence of NHL was identified. Therefore, acquired C1 inhibitor deficiency heralded a recurrence, although this had not been a manifestation when NHL was first diagnosed. The patient underwent a further course of chemotherapy and remains well, although C1 inhibitor, C1q, C2, and C4 levels remain reduced.
本文描述了一名中年患者，其在牙科治疗后出现口面部组织反复肿胀发作。经检查，C1抑制剂、C1q、C2和C4水平均显著降低，诊断为获得性C1抑制剂缺乏症。该患者2年前被诊断为非霍奇金淋巴瘤（NHL），并接受了成功的化疗疗程。她血管性水肿发作的出现促使进行了全面复查，结果发现NHL复发。因此，获得性C1抑制剂缺乏症预示着复发，尽管在首次诊断NHL时这并非其表现。患者接受了进一步的化疗疗程，目前情况良好，尽管C1抑制剂、C1q、C2和C4水平仍降低。
