骨肉瘤：过去与现在。在皇家阿尔弗雷德王子医院的五十年回顾。

Osteosarcoma: then and now. A fifty year review at Royal Prince Alfred Hospital.

作者信息

Marsden F W, Sharland M

机构信息

Department of Orthopaedics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

出版信息

Aust N Z J Surg. 1992 Jan;62(1):45-51. doi: 10.1111/j.1445-2197.1992.tb05353.x.

DOI:10.1111/j.1445-2197.1992.tb05353.x

PMID:1731737

Abstract

The purpose of this study is to review survival, treatment methods and criteria for diagnosis of osteosarcoma at Royal Prince Alfred Hospital during two periods in the last 50 years. The records of 22 patients diagnosed with osteosarcoma and nine with osteosarcoma in Paget's disease (from 1939 to 1950) were reviewed. All but one had died within three years. One patient survived six years. The second series was taken from 1983 to 1990. Forty-nine patients, including three with Paget's sarcoma, were studied. Probability of survival was estimated by actuarial analysis using Kaplan-Meier curves. Overall survival was estimated at 45%. Those patients who were free of metastatic disease at the conclusion of their treatment were estimated to have a probability of survival of 85%.

摘要

本研究的目的是回顾过去50年中两个时间段里，在皇家阿尔弗雷德王子医院诊断出的骨肉瘤患者的生存情况、治疗方法及诊断标准。回顾了1939年至1950年间诊断为骨肉瘤的22例患者以及9例佩吉特病骨肉瘤患者的记录。除1例患者外，其他所有患者均在三年内死亡。1例患者存活了6年。第二个系列选取的是1983年至1990年间的病例。共研究了49例患者，其中包括3例佩吉特肉瘤患者。采用Kaplan-Meier曲线通过精算分析来估计生存概率。总体生存率估计为45%。那些在治疗结束时没有转移疾病的患者，其生存概率估计为85%。