Katzer A, Beecken W D, Meenen N M, Jungbluth K H, Delling G
Abteilung für Unfall- und Wiederherstellungschirurgie, Universitätskrankenhaus Hamburg-Eppendorf, in Zusammenarbeit mit dem Zentrum für Biomechanik des UKE.
Unfallchirurgie. 1997 Feb;23(1):18-22.
Pathological fracture in histologically proven post-Paget osteosarcoma of the humerus is a rare complication. Due to individual requests as well as age and comorbidity, a course of primary palliative treatment was chosen in the present case. Survival time after diagnosis was 9 months and the patient died of a tumor-independent disease. Even in combined treatment, consisting of surgery and (neo-)adjuvant radio-/chemotherapy, prognosis of osteosarcomas secondary to Paget's disease remains very disappointing. Therefore, in treatment of this highly lethal tumor the patient's individual requests and personal situation often require more consideration than in many other malignancies.
组织学确诊的肱骨佩吉特病后骨肉瘤发生病理性骨折是一种罕见的并发症。鉴于个人诉求以及年龄和合并症情况，本病例选择了一线姑息治疗方案。诊断后的生存时间为9个月，患者死于与肿瘤无关的疾病。即使采用手术和（新）辅助放疗/化疗的联合治疗，佩吉特病继发骨肉瘤的预后仍然非常令人失望。因此，在治疗这种高致死性肿瘤时，与许多其他恶性肿瘤相比，患者的个人诉求和自身情况往往需要更多考虑。
