系统性硬化症患者中针对U3核仁核糖核蛋白（纤维原蛋白）的自身抗体。
Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis.
作者信息
Okano Y, Steen V D, Medsger T A
机构信息
Department of Medicine, University of Pittsburgh School of Medicine, PA 15261.
出版信息
Arthritis Rheum. 1992 Jan;35(1):95-100. doi: 10.1002/art.1780350114.
To determine the clinical significance of serum antibodies to the U3 small nuclear ribonucleoprotein particle ([U3]snRNP), we studied sera from 416 patients with systemic sclerosis (SSc) and 264 controls, using immunofluorescence and immunoprecipitation assays. The presence of serum anti-(U3)snRNP was highly specific to SSc, was found more frequently in blacks, and was associated with skeletal muscle disease and primary pulmonary arterial hypertension. These antibodies may identify one or more unusual clinical subsets of SSc.
为了确定血清抗U3小核糖核蛋白颗粒（[U3]snRNP）抗体的临床意义，我们使用免疫荧光和免疫沉淀试验，研究了416例系统性硬化症（SSc）患者和264名对照者的血清。血清抗（U3）snRNP的存在对SSc具有高度特异性，在黑人中更常见，并且与骨骼肌疾病和原发性肺动脉高压相关。这些抗体可能识别出SSc的一个或多个不寻常的临床亚组。
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