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乳腺分化抗原NY-BR-1在外阴叶状肿瘤中的表达。

Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva.

作者信息

Giger Olivier T, Lacoste Elena, Honegger Christoph, Padberg Barbara, Moch Holger, Varga Zsuzsanna

机构信息

Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland.

出版信息

Virchows Arch. 2007 Apr;450(4):471-4. doi: 10.1007/s00428-007-0377-8. Epub 2007 Feb 21.

DOI:10.1007/s00428-007-0377-8
PMID:17318573
Abstract

We describe a phyllodes tumor of borderline malignancy in the labium majus of a 49-year-old woman. The histogenetic origin of phyllodes tumors in the vulva is controversial. Strong immunoreactivity for NY-BR-1, a novel breast differentiation antigen, was demonstrated within the epithelial components of the phyllodes tumor. A similar expression pattern was observed in mammary-like glands of the vulva. These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue.

摘要

我们描述了一名49岁女性大阴唇的交界性恶性叶状肿瘤。外阴叶状肿瘤的组织发生起源存在争议。在叶状肿瘤的上皮成分中证实了对一种新型乳腺分化抗原NY-BR-1的强免疫反应性。在外阴的乳腺样腺体中观察到类似的表达模式。这些发现提供了进一步的证据，表明外阴叶状肿瘤可能起源于大阴唇的乳腺样腺体或异位乳腺组织。

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A 69-year-old woman with a vulvar lesion. Phyllodes tumor of the vulva.一名69岁患有外阴病变的女性。外阴叶状肿瘤。
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Cancer testis antigens and NY-BR-1 expression in primary breast cancer: prognostic and therapeutic implications.原发性乳腺癌中的癌睾丸抗原和 NY-BR-1 表达：预后和治疗意义。
BMC Cancer. 2013 Jun 3;13:271. doi: 10.1186/1471-2407-13-271.
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