Angelo Joe S, Kar Bikash Ranjan, Thomas Jayakar
Department of Dermatology, SLR and TC, Karigiri, Vellore, India.
Indian J Dermatol Venereol Leprol. 2007 Jan-Feb;73(1):65. doi: 10.4103/0378-6323.30663.
No controlled data is available till date comparing topical tazarotene and clobetasol in Indian psoriatic patients.
The aim was to compare the clinical efficacy of 12 weeks of once-daily tazarotene 0.1% cream with that of once-daily clobetasol propionate 0.05% cream in the treatment of patients with chronic plaque psoriasis.
About 36 patients with bilaterally symmetrical lesions were enrolled in this double-blind randomized controlled study. A left-right randomized study was conducted.
Clobetasol cream was better than tazarotene cream in reducing the erythema throughout the treatment period with statistically significant differences favoring clobetasol at weeks 2, 4, 6 and 8 ( P <0.05). Tazarotene was better in reducing the induration at weeks 2 ( P <0.05), 4, 10 and 12. Clobetasol cream was better in reducing the scaling throughout the treatment period with statistically significant differences favoring clobetasol over the entire treatment period. Treatment success rate was 100% with clobetasol and 88% with tazarotene at the end of week 12 with clobetasol achieving 100% success rate at the end of week 6. Treatment with tazarotene resulted in uniform reduction of plaque elevation and was not associated with the development of hot spots.
Topical tazarotene 0.1% cream is less effective than topical clobetasol propionate 0.05% cream in the treatment of plaque psoriasis. It has more effect on induration than on erythema and scaling of psoriatic lesions.
迄今为止，尚无对照数据可用于比较印度银屑病患者使用外用他扎罗汀和丙酸氯倍他索的情况。
本研究旨在比较0.1%他扎罗汀乳膏每日一次使用12周与0.05%丙酸氯倍他索乳膏每日一次治疗慢性斑块状银屑病患者的临床疗效。
约36例双侧对称皮损患者纳入本双盲随机对照研究。进行了一项左右随机研究。
在整个治疗期间，丙酸氯倍他索乳膏在减轻红斑方面优于他扎罗汀乳膏，在第2、4、6和8周差异有统计学意义，支持丙酸氯倍他索（P<0.05）。他扎罗汀在第2周（P<0.05）、第4、10和12周减轻硬结方面效果更好。丙酸氯倍他索乳膏在整个治疗期间减轻鳞屑方面效果更好，在整个治疗期间差异有统计学意义，支持丙酸氯倍他索。在第12周结束时，丙酸氯倍他索的治疗成功率为100%，他扎罗汀为88%，丙酸氯倍他索在第6周结束时成功率达到100%。使用他扎罗汀治疗可使斑块隆起均匀降低，且未出现热点。
0.1%他扎罗汀外用乳膏在治疗斑块状银屑病方面不如0.05%丙酸氯倍他索外用乳膏有效。它对银屑病皮损硬结的影响大于对红斑和鳞屑的影响。
