每日一次的他扎罗汀凝胶与每日两次的氟轻松乳膏治疗斑块状银屑病的对比

Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis.

作者信息

Lebwohl M, Ast E, Callen J P, Cullen S I, Hong S R, Kulp-Shorten C L, Lowe N J, Phillips T J, Rosen T, Wolf D I, Quell J M, Sefton J, Lue J C, Gibson J R, Chandraratna R A

机构信息

Mount Sinai Medical Center, New York, New York 10029, USA.

出版信息

J Am Acad Dermatol. 1998 May;38(5 Pt 1):705-11. doi: 10.1016/s0190-9622(98)70594-8.

DOI:10.1016/s0190-9622(98)70594-8

PMID:9591815

Abstract

BACKGROUND

A new class of topical receptor-selective acetylenic retinoids, the first of which is tazarotene, has been developed.

OBJECTIVE

Our purpose was to compare the safety, efficacy, and duration of therapeutic effect of 12 weeks of once-daily tazarotene 0.1% and 0.05% gel with that of twice-daily fluocinonide 0.05% cream in the treatment of patients with plaque psoriasis.

METHODS

Three hundred forty-eight patients with plaque psoriasis were enrolled and 275 patients completed a multicenter, investigator-masked, randomized, parallel-group clinical trial.

RESULTS

Both tazarotene gels were as effective as fluocinonide in reducing plaque elevation after 1 week of treatment, and tazarotene 0.1% gel was similar to fluocinonide in reducing scaling of trunk/limb lesions at all study weeks except week 4. Tazarotene 0. 1% gel was similar to fluocinonide in reducing scaling of knee/elbow lesions at weeks 8 and 12. Fluocinonide had a significantly greater effect on erythema than tazarotene at weeks 2 through 8. However, treatments were not significantly different at week 12, and tazarotene demonstrated significantly better maintenance of therapeutic effect after cessation of therapy.

CONCLUSION

Tazarotene 0.1% and 0.05% gels were safe and effective in the treatment of mild-to-moderate plaque psoriasis.

摘要

背景

已研发出一类新型的局部受体选择性乙炔类维甲酸，其中首个药物为他扎罗汀。

目的

我们的目的是比较每日一次使用0.1%和0.05%他扎罗汀凝胶治疗12周与每日两次使用0.05%氟轻松乳膏治疗斑块状银屑病患者的安全性、疗效及治疗效果持续时间。

方法

招募了348例斑块状银屑病患者，275例患者完成了一项多中心、研究者设盲、随机、平行组临床试验。

结果

治疗1周后，两种他扎罗汀凝胶在减轻斑块隆起方面与氟轻松效果相当，在除第4周外的所有研究周，0.1%他扎罗汀凝胶在减轻躯干/肢体皮损鳞屑方面与氟轻松相似。在第8周和第12周，0.1%他扎罗汀凝胶在减轻膝/肘皮损鳞屑方面与氟轻松相似。在第2周至第8周，氟轻松在减轻红斑方面的效果显著优于他扎罗汀。然而，在第12周时治疗效果无显著差异，且他扎罗汀在停药后治疗效果的维持方面表现显著更好。