Akujobi C N, Nwaigwe C G, Egwuatu T O, Ogunsola F T
Department of Medical Microbiology/Parasitology, Nnamdi Azikiwe University Teaching Hospital Nnewi.
Niger J Clin Pract. 2006 Dec;9(2):169-73.
Secondary peritonitis is a common and serious form of intra-abdominal infection, often associated with high morbidity and mortality. The overall patient outcome has not markedly improved in spite of advances in patient management. There is therefore need to study the pattern of bacterial pathogens associated with secondary peritonitis in Lagos University Teaching Hospital (LUTH) and the antibiotic susceptibility pattern as that would help in formulation of empiric antibiotic policy on peritonitis and improve the outcome/prognosis of the patients. A prospective study of 35 patients with suspected peritonitis at LUTH between February, 2002 and June 2003 was done. Peritoneal fluids of these patients were collected intra-operatively under aseptic conditions. The specimens were subjected to aerobic and anaerobic studies. Twenty-seven isolates were identified aerobically with Escherichia coli being the most predominant organism 11 (31.4%) followed by Staphylococcus aureus 6 (17.1%) then Klebsiella spp 4 (11.4%). Anaerobic culture showed Prevotella species as the most predominant 14 (40%) followed by Bacteroides fragilis group 8 (22.9%). Overall, Prevotella species were the most predominant organisms isolated in LUTH patients with secondary peritonitis.
继发性腹膜炎是一种常见且严重的腹腔内感染形式，常伴有高发病率和死亡率。尽管在患者管理方面取得了进展，但患者的总体预后并未显著改善。因此，有必要研究拉各斯大学教学医院（LUTH）继发性腹膜炎相关的细菌病原体模式以及抗生素敏感性模式，这将有助于制定腹膜炎的经验性抗生素策略，并改善患者的预后。对2002年2月至2003年6月期间LUTH的35例疑似腹膜炎患者进行了一项前瞻性研究。在无菌条件下于手术中收集这些患者的腹腔液。对标本进行需氧和厌氧研究。需氧培养鉴定出27株分离菌，其中大肠埃希菌最为常见，有11株（31.4%），其次是金黄色葡萄球菌6株（17.1%），然后是克雷伯菌属4株（11.4%）。厌氧培养显示普雷沃菌属最为常见，有14株（40%），其次是脆弱拟杆菌群8株（22.9%）。总体而言，普雷沃菌属是LUTH继发性腹膜炎患者中分离出的最主要病原体。
