Ohanaka C E, Ollu-Eddo A N
Department of Surgery and Pathology, College of Medical Sciences, University of Benin, P.M.B. 1154, Benin City, Nigeria.
Niger J Clin Pract. 2006 Dec;9(2):179-82.
Out of a total of 240 patients who were managed at the University of Benin Teaching Hospital, Nigeria, for breast cancer over a ten year period (January 1995-December 2004, 8 (3.3%) were found to have Paget's disease of the nipple-areolar complex. They were all females aged between 38-60 (mean 47.62 years). Duration of symptoms before presentation was between 5 months and 7 years (mean 20.75 months). The left breast was more affected than the right. They all presented with itching, excoriation and ulceration of the nipple and diagnosis was by wedge biopsy of the nipple in early cases and by incisional biopsy in late cases. Most presented with advanced disease. Seven patients had mastectomy while one declined surgery. They all had chemotherapy and tamoxifen. Five died within one year of surgery while the remaining three were lost to follow up. Paget's disease, though rare, requires a high index of suspicion for proper diagnosis.
在尼日利亚贝宁大学教学医院接受治疗的240例乳腺癌患者中，在十年期间（1995年1月至2004年12月），发现8例（3.3%）患有乳头乳晕复合体佩吉特病。她们均为女性，年龄在38至60岁之间（平均47.62岁）。就诊前症状持续时间在5个月至7年之间（平均20.75个月）。左乳比右乳受影响更严重。她们均表现为乳头瘙痒、表皮脱落和溃疡，早期病例通过乳头楔形活检诊断，晚期病例通过切除活检诊断。大多数患者就诊时已处于疾病晚期。7例患者接受了乳房切除术，1例拒绝手术。她们均接受了化疗和他莫昔芬治疗。5例患者在手术后一年内死亡，其余3例失访。佩吉特病虽然罕见，但需要高度怀疑才能做出正确诊断。
