Aguiar Bujanda David, Rivero Vera José Carlos, Cabrera Suárez Miguel Angel, Aguiar Morales José, Christol Rémy, Bohn Sarmiento Uriel, Domínguez Cabrera Casimira, Le Bouc Yves
Servicio de Oncología Médica, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Breast J. 2007 Mar-Apr;13(2):189-91. doi: 10.1111/j.1524-4741.2007.00398.x.
Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.
非胰岛细胞瘤性低血糖症（NICTH）并不常见，且与肿瘤产生胰岛素样生长因子II或其高分子量前体（大IGF-II）有关。NICTH病例与不同肿瘤有关，主要是肉瘤。然而，此前仅报道过3例继发于乳腺叶状肿瘤（PTB）的病例。我们报告了一名患有巨大PTB的女性的临床病程，该患者因肿瘤产生大IGF-II继发了不可逆的低血糖昏迷。还对该罕见病症的文献进行了简要回顾并阐述了可能的机制。
