Saha Samir, Berglund Margareta, Sylvén Christer, Gordon Allan, Agewall Stefan
Int J Cardiol. 2008 Jan 11;123(2):195-6. doi: 10.1016/j.ijcard.2006.11.136. Epub 2007 Feb 22.
Ten patients with chronic stable angina pectoris and ten aged-matched healthy controls were investigated. Aspirin was given as 160 mg/day and clopidogrel as 300 mg loading dose followed by 75 mg/day. Whole blood aggregometry was performed at baseline and after 10 days with collagen or ADP as stimulator. ADP as well as collagen-induced platelet aggregation was each reduced (P<0.02) both in healthy volunteers and in patients with stable angina pectoris with combination therapy compared with aspirin only. In conclusion, treatment with clopidogrel and aspirin provides significantly greater inhibition of platelet activity than aspirin alone in patients with stable angina pectoris and in healthy control subjects.
对10例慢性稳定型心绞痛患者和10例年龄匹配的健康对照者进行了研究。给予阿司匹林160毫克/天，氯吡格雷负荷剂量300毫克，随后75毫克/天。在基线时以及10天后，以胶原蛋白或二磷酸腺苷（ADP）作为刺激剂进行全血凝集试验。与仅使用阿司匹林相比，联合治疗使健康志愿者和稳定型心绞痛患者体内ADP以及胶原蛋白诱导的血小板聚集均降低（P<0.02）。总之，在稳定型心绞痛患者和健康对照者中，氯吡格雷与阿司匹林联合治疗对血小板活性的抑制作用明显大于单独使用阿司匹林。
