Sato Takashi, Takahashi Satoshi, Mizumoto Takao, Harao Michiko, Akizuki Miwa, Takasugi Miyuki, Fukutomi Takashi, Yamashita Jun-ichi
Department of Otolaryngology, Aichi-Gakuin University, Suemori-dori 2-11, Chikusa-ku 464-8651, Aichi, Japan.
Surg Oncol. 2006 Dec;15(4):217-22. doi: 10.1016/j.suronc.2007.01.003. Epub 2007 Feb 22.
This mini-review summarizes our recent experimental and clinical studies on neutrophil elastase (NE) and cancer based on our original view point. Neoplasms metastasize as a result of a complex series of events. This process requires various degradative enzymes including proteases. NE has broad substrate specificity under physiological conditions, and excessive NE results in digestion of not only elastin, but also other extracellular matrix proteins. Several cell lines from human breast cancer and human lung cancer produce immunoreactive NE. The amount of immunoreactive NE in tumor tissue is an independent prognostic indicator of patients with breast cancer and lung cancer. Furthermore, a specific NE inhibitor completely suppressed growth of cancer cells transplanted into severe combined immunodeficiency mice. The use of NE inhibitor would seem to be a promising way to prevent the invasion and metastasis of cancer.
本综述基于我们的原创观点，总结了我们最近关于中性粒细胞弹性蛋白酶（NE）与癌症的实验和临床研究。肿瘤转移是一系列复杂事件的结果。这个过程需要包括蛋白酶在内的各种降解酶。NE在生理条件下具有广泛的底物特异性，过量的NE不仅会导致弹性蛋白的消化，还会导致其他细胞外基质蛋白的消化。几种人乳腺癌和人肺癌细胞系可产生免疫反应性NE。肿瘤组织中免疫反应性NE的量是乳腺癌和肺癌患者的独立预后指标。此外，一种特异性NE抑制剂可完全抑制移植到严重联合免疫缺陷小鼠体内的癌细胞的生长。使用NE抑制剂似乎是预防癌症侵袭和转移的一种有前景的方法。
