Gallant Peter
Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Trends Cell Biol. 2007 Apr;17(4):187-92. doi: 10.1016/j.tcb.2007.02.005. Epub 2007 Feb 22.
Pontin and Reptin are two closely related members of the AAA+ family of DNA helicases. They have roles in diverse cellular processes, including the response to DNA double-strand breaks and the control of gene expression. The two proteins share residence in different multiprotein complexes, such as the Tip60, Ino80, SRCAP and Uri1 complexes in animals, which are involved (directly or indirectly) in transcriptional regulation, but they also function independently from each other. Both Reptin and Pontin repress certain transcriptional targets of Myc, but only Reptin is required for the repression of specific beta-catenin and nuclear factor-kappaB targets. Here, I review recent studies that have addressed the mechanisms of transcriptional control by Pontin and Reptin.
Pontin和Reptin是AAA+家族DNA解旋酶中两个密切相关的成员。它们在多种细胞过程中发挥作用，包括对DNA双链断裂的反应和基因表达的调控。这两种蛋白质共同存在于不同的多蛋白复合物中，如动物中的Tip60、Ino80、SRCAP和Uri1复合物，这些复合物直接或间接地参与转录调控，但它们也能独立发挥作用。Reptin和Pontin都能抑制Myc的某些转录靶点，但只有Reptin是抑制特定β-连环蛋白和核因子-κB靶点所必需的。在此，我综述了近期关于Pontin和Reptin转录调控机制的研究。
