染色质修饰及其功能。

Chromatin modifications and their function.

作者信息

Kouzarides Tony

机构信息

The Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QN, UK.

出版信息

Cell. 2007 Feb 23;128(4):693-705. doi: 10.1016/j.cell.2007.02.005.

DOI:10.1016/j.cell.2007.02.005

PMID:17320507

Abstract

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.

摘要

核小体表面镶嵌着多种修饰。迄今为止，已鉴定出至少八种不同类型，且每种类型都有许多不同的修饰位点。从功能上讲，这些修饰要么通过破坏染色质接触，要么通过影响非组蛋白与染色质的结合来发挥作用。它们在组蛋白上的存在能够决定DNA包装其中的高阶染色质结构，并能精心安排酶复合物的有序募集以操控DNA。通过这种方式，组蛋白修饰有可能影响许多基本生物学过程，其中一些过程可能会发生表观遗传继承。