Cherrill D A, Stote R M, Birge J R, Singer I
Ann Intern Med. 1975 Nov;83(5):654-6. doi: 10.7326/0003-4819-83-5-654.
We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.
我们研究了去甲金霉素对一名抗利尿激素（ADH）分泌异常综合征患者水代谢的影响，该患者血清钠浓度为110毫当量/升。在去甲金霉素治疗前、治疗期间及治疗后对自由水清除率进行了研究。本研究表明，去甲金霉素（900毫克/天）在肿瘤诱导的ADH分泌情况下至少能部分抑制ADH的作用，产生可逆的部分性肾性尿崩症，且副作用很少或没有。去甲金霉素可能对慢性抗利尿激素分泌异常的治疗有用。
