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颈髓损伤后阻塞性睡眠呼吸暂停低通气综合征的估计患病率。

Estimated prevalence of obstructive sleep apnea-hypopnea syndrome after cervical cord injury.

作者信息

Leduc Bernard E, Dagher Jehan H, Mayer Pierre, Bellemare François, Lepage Yves

机构信息

Department of Physical Medicine and Rehabilitation, Institut de Réadaptation de Montréal, and Respiratory Division and Sleep Laboratory, Centre Hospitalier de l'Université de Montréal-Hôpital Hôtel-Dieu, QC, Canada.

出版信息

Arch Phys Med Rehabil. 2007 Mar;88(3):333-7. doi: 10.1016/j.apmr.2006.12.025.

Abstract

OBJECTIVES

To estimate the prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with cervical cord injury and to identify predictive factors.

DESIGN

Cross-sectional study.

SETTING

Rehabilitation center.

PARTICIPANTS

Forty-one adults with cervical cord injury of more than 6 months in duration.

INTERVENTIONS

Medical history, physical exam, and full in home overnight polysomnography were undertaken. Data were collected on characteristics of spinal cord injury, current medication, sleeping habits, daytime sleepiness, body mass index (BMI), and neck circumference.

MAIN OUTCOME MEASURE

Presence or absence of OSAHS as defined by the American Academy of Sleep Medicine criteria (1999).

RESULTS

Twenty-two (53%) patients (95% confidence interval [CI], 38.4%-68.9%) had OSAHS. Daytime sleepiness (odds ratio [OR], 41.1; 95% CI, 2.3-739.7; P=.02), BMI of 30 kg/m2 or higher (OR=17.2; 95% CI, 1.4-206.4; P=.03), and 3 or more awakenings during sleep (OR=34; 95% CI, 1.6-744.8; P=.03) were the best predictive factors of OSAHS obtained by a forward stepwise multiple logistic regression.

CONCLUSIONS

The estimated prevalence of OSAHS is high after cervical cord injury. OSAHS should be suspected, especially in patients with daytime sleepiness, obesity, and frequent awakenings during sleep.

摘要

目的

评估颈髓损伤患者阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的患病率,并确定预测因素。

设计

横断面研究。

地点

康复中心。

参与者

41名颈髓损伤超过6个月的成年人。

干预措施

进行病史采集、体格检查及全夜家庭多导睡眠图监测。收集脊髓损伤特征、当前用药情况、睡眠习惯、日间嗜睡情况、体重指数(BMI)及颈围等数据。

主要观察指标

根据美国睡眠医学学会标准(1999年)定义的OSAHS的有无。

结果

22名(53%)患者(95%置信区间[CI],38.4%-68.9%)患有OSAHS。日间嗜睡(优势比[OR],41.1;95%CI,2.3-739.7;P=0.02)、BMI为30kg/m2或更高(OR=17.2;95%CI,1.4-206.4;P=0.03)以及睡眠中3次或更多次觉醒(OR=34;95%CI,1.6-744.8;P=0.03)是通过向前逐步多元逻辑回归得出的OSAHS的最佳预测因素。

结论

颈髓损伤后OSAHS的估计患病率较高。应怀疑存在OSAHS,尤其是日间嗜睡、肥胖及睡眠中频繁觉醒的患者。

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