通过S-100蛋白染色证实结节性痒疹患者乳头真皮层神经数量增加。
Demonstration by S-100 protein staining of increased numbers of nerves in the papillary dermis of patients with prurigo nodularis.
作者信息
Harris B, Harris K, Penneys N S
机构信息
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL.
出版信息
J Am Acad Dermatol. 1992 Jan;26(1):56-8. doi: 10.1016/0190-9622(92)70006-2.
BACKGROUND
We hypothesized that hyperplasia of papillary dermal nerves was a constant feature of prurigo nodularis.
OBJECTIVE
We tested this hypothesis by examining sections from 25 cases of prurigo nodularis, 25 cases of skin lesions characterized by epidermal hyperplasia without clinical pruritus, and 22 cases of clinically pruritic dermatoses with variable degrees of epidermal response for the presence of papillary dermal nerves.
METHODS
We used a standard immunohistochemical assay with an antibody to S-100 protein as a means of identification of nerves.
RESULTS
In 24 of 25 cases of prurigo nodularis, papillary dermal nerves were identified by immunostaining. Cutaneous nerves were present in 1 of 22 cases of epidermal hyperplasia with pruritus and were absent in the papillary dermis in nonpruritic cases.
CONCLUSION
We conclude that hypertrophy of cutaneous papillary dermal nerves is a relatively constant feature of prurigo nodularis. The presence of papillary dermal nerves suggests a neurocutaneous component in the pathogenesis of prurigo nodularis.
背景
我们推测乳头层真皮神经增生是结节性痒疹的一个恒定特征。
目的
我们通过检查25例结节性痒疹、25例以表皮增生为特征但无临床瘙痒的皮肤病变以及22例有不同程度表皮反应的临床瘙痒性皮肤病的切片，来检验这一假设，以确定乳头层真皮神经的存在情况。
方法
我们使用针对S-100蛋白的抗体进行标准免疫组织化学检测，以此作为识别神经的方法。
结果
在25例结节性痒疹病例中，有24例通过免疫染色鉴定出乳头层真皮神经。在22例有瘙痒症状的表皮增生病例中，有1例存在皮神经，而在无瘙痒症状的病例中，乳头层真皮中未发现皮神经。
结论
我们得出结论，皮肤乳头层真皮神经肥大是结节性痒疹相对恒定的特征。乳头层真皮神经的存在提示结节性痒疹发病机制中存在神经皮肤成分。
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