舒尔曼综合征（嗜酸性粒细胞增多性弥漫性筋膜炎）与嗜酸性粒细胞增多性肌痛综合征相关筋膜炎的组织病理学比较。

A histopathologic comparison of Shulman's syndrome (diffuse fasciitis with eosinophilia) and the fasciitis associated with the eosinophilia-myalgia syndrome.

作者信息

Feldman S R, Silver R M, Maize J C

机构信息

Department of Dermatology, Medical University of South Carolina, Charleston.

出版信息

J Am Acad Dermatol. 1992 Jan;26(1):95-100. doi: 10.1016/0190-9622(92)70014-7.

DOI:10.1016/0190-9622(92)70014-7

PMID:1732344

Abstract

A comparison of the histopathologic features of Shulman's syndrome (diffuse fasciitis with eosinophilia) and the fasciitis associated with the eosinophilia-myalgia syndrome is presented. The study population consisted of eight biopsy specimens of seven patients with Shulman's syndrome and 11 specimens from 10 patients with eosinophilia-myalgia syndrome. Both groups exhibited inflammatory changes in the subcutaneous fat, septa, and fascia; cutaneous changes were more prominent in cases of eosinophilia-myalgia syndrome. Eosinophils and plasma cells were not consistently present in either condition; mast cells and factor XIIIa-positive cells were consistently present in the inflammatory infiltrates. Although there was overlap in the histopathologic findings, Shulman's syndrome tends to involve the subcutis alone and the eosinophilia-myalgia syndrome tends to be a pancutaneous-subcutaneous process.

摘要

本文对舒尔曼综合征（嗜酸性粒细胞增多性弥漫性筋膜炎）和与嗜酸性粒细胞增多性肌痛综合征相关的筋膜炎的组织病理学特征进行了比较。研究对象包括7例舒尔曼综合征患者的8份活检标本以及10例嗜酸性粒细胞增多性肌痛综合征患者的11份标本。两组均在皮下脂肪、间隔和筋膜出现炎症改变；嗜酸性粒细胞增多性肌痛综合征患者的皮肤改变更为显著。嗜酸性粒细胞和浆细胞在两种情况中均并非始终存在；肥大细胞和因子XIIIa阳性细胞始终存在于炎症浸润中。尽管组织病理学发现存在重叠，但舒尔曼综合征往往仅累及皮下组织，而嗜酸性粒细胞增多性肌痛综合征往往是全皮肤-皮下的病变过程。