全国双胞胎队列中的系统性红斑狼疮及相关系统性疾病：同卵双胞胎中疾病患病率增加及疾病特征的一致性

Systemic lupus erythematosus and related systemic diseases in a nationwide twin cohort: an increased prevalence of disease in MZ twins and concordance of disease features.

作者信息

Järvinen P, Kaprio J, Mäkitalo R, Koskenvuo M, Aho K

机构信息

Rheumatism Foundation Hospital, Heinola, Finland.

出版信息

J Intern Med. 1992 Jan;231(1):67-72. doi: 10.1111/j.1365-2796.1992.tb00500.x.

DOI:10.1111/j.1365-2796.1992.tb00500.x

PMID:1732401

Abstract

Concordance rates for systemic rheumatic diseases among monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs ascertained from the older (twins born before 1958) and younger (twins born during the period 1958-1986) parts of the Finnish Twin Cohort were studied. Nine MZ pairs and 10 DZ pairs with at least one member affected by systemic lupus erythematosus (SLE) were identified. Only one MZ pair was concordant for definite SLE by American Rheumatism Association (ARA) criteria. In addition, two more MZ pairs that fulfilled three ARA criteria may have been concordant. None of the DZ pairs were concordant for SLE. MZ twins also had a higher concordance rate for tests of autoantibodies, but the numbers were small. Other systemic rheumatic diseases were infrequent. The cumulative incidence of systemic rheumatic diseases among MZ twin individuals (1.7/1000) was significantly higher than that among DZ twin individuals (0.7/1000).

摘要

对从芬兰双胞胎队列中年龄较大（1958年以前出生的双胞胎）和年龄较小（1958 - 1986年期间出生的双胞胎）部分确定的单卵（MZ）和同性双卵（DZ）双胞胎对中系统性风湿性疾病的一致率进行了研究。确定了9对MZ双胞胎和10对DZ双胞胎，其中至少有一名成员患有系统性红斑狼疮（SLE）。根据美国风湿病协会（ARA）标准，只有一对MZ双胞胎对确诊的SLE一致。此外，还有两对满足三项ARA标准的MZ双胞胎对可能也是一致的。没有一对DZ双胞胎对SLE一致。MZ双胞胎在自身抗体检测中的一致率也更高，但数量较少。其他系统性风湿性疾病并不常见。MZ双胞胎个体中系统性风湿性疾病的累积发病率（1.7/1000）显著高于DZ双胞胎个体（0.7/1000）。