Needleman Ian, Suvan Jean, Gilthorpe Mark S, Tucker Richard, St George Geoff, Giannobile William, Tonetti Maurizio, Jarvis Martin
Department of Periodontology and International Centre for Evidence-Based Oral Health, UCL Eastman Dental Institute, London, UK.
J Clin Periodontol. 2007 Apr;34(4):325-33. doi: 10.1111/j.1600-051X.2007.01058.x. Epub 2007 Feb 23.
BACKGROUND/AIM: Tobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy.
This was a parallel arm, randomized, identical placebo-controlled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling.
Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level -0.19 mm/month (95% CI=-0.34, 0.04; p=0.012) and probing depth 0.30 mm/month (95% CI=-0.42, -0.17; p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months.
This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers.
背景/目的：吸烟会降低非手术牙周治疗的效果。低剂量强力霉素（LDD）进行宿主调节可能有利于组织修复并促进治疗反应的改善。本研究的目的是调查LDD对吸烟者非手术牙周治疗的影响。
这是一项双臂平行、随机、采用相同安慰剂对照的试验，对检查者、护理人员、参与者和统计人员进行了盲法处理，并进行6个月的随访。患者接受非手术治疗以及3个月的试验药物或对照药物治疗。统计分析采用传统方法和多水平模型。
18名对照组患者和16名试验组患者完成了研究。试验组临床附着水平的变化速度在统计学上更快，为-0.19毫米/月（95%置信区间=-0.34, 0.04；p=0.012），探诊深度为0.30毫米/月（95%置信区间=-0.42, -0.17；p<0.001）。然而，6个月时临床或生化指标的绝对变化未观察到差异。
本研究没有提供证据表明在吸烟者中使用LDD作为非手术牙周治疗辅助手段有好处。
