University Hospitals of Cleveland, Case Medical Center, Division of Gastroenterology and Hepatology, WRN5466, 11100 Euclid Avenue, Cleveland, OH 44106-5066, USA.
Curr Infect Dis Rep. 2007 Mar;9(2):110-5. doi: 10.1007/s11908-007-0005-4.
Both diabetes and chronic hepatitis C virus (HCV) infection are common conditions that often coexist in the same subject. Studies seem to confirm the presence of an association between them. Mechanisms leading to HCV-induced insulin resistance and glucose intolerance are beginning to be elucidated. Insulin resistance in the setting of chronic HCV infection could be related etiologically to viral factors but is also often seen with concomitant nonalcoholic fatty liver disease, the hepatic manifestation of the metabolic syndrome. Insulin resistance decreases the likelihood of response to interferon-based therapies and may be an independent risk factor for the progression of HCV-related liver disease.
糖尿病和慢性丙型肝炎病毒（HCV）感染都是常见的疾病，常常在同一患者中同时存在。研究似乎证实了两者之间存在关联。导致 HCV 引起的胰岛素抵抗和葡萄糖耐量受损的机制开始被阐明。在慢性 HCV 感染的情况下，胰岛素抵抗可能与病毒因素有关，但也经常与同时存在的非酒精性脂肪性肝病（代谢综合征的肝脏表现）有关。胰岛素抵抗降低了对基于干扰素的治疗的反应可能性，并且可能是 HCV 相关肝病进展的独立危险因素。
