Tze W J, Saunders J, Drummond G I
Arch Dis Child. 1975 Aug;50(8):656-8. doi: 10.1136/adc.50.8.656.
Measurement of urinary cyclic AMP (adenosine 3'5'-cyclic phosphate) and examination of calcium and phosphorus metabolism was carried out in two children with pseudohypoparathyroidism. In both patients infusion of parathyroid hormone failed to elicit any change in urinary cyclic AMP, while a dose-dependent increase in urinary cyclic AMP occurred in a normal control. The findings agree with concept of unresponsiveness of renal cortical tissue to parathyroid hormone in pseudohypoparathyroidism and provide further evidence that measurement of urinary cyclic AMP during parathyroid hormone infusion may be the method of choice in the diagnosis of this disease.
对两名假性甲状旁腺功能减退症患儿进行了尿中环磷酸腺苷（3',5'-环磷酸腺苷）的测定以及钙和磷代谢检查。在这两名患者中，静脉注射甲状旁腺激素均未能引起尿中环磷酸腺苷的任何变化，而在一名正常对照者中，尿中环磷酸腺苷出现了剂量依赖性增加。这些发现与假性甲状旁腺功能减退症中肾皮质组织对甲状旁腺激素无反应的概念相符，并进一步证明在静脉注射甲状旁腺激素期间测定尿中环磷酸腺苷可能是诊断该病的首选方法。
