尿3',5'-环磷酸腺苷。假性甲状旁腺功能减退症的诊断试验。

Urinary 3'5' cyclic AMP. Diagnostic test in pseudohypoparathyroidism.

作者信息

Tze W J, Saunders J, Drummond G I

出版信息

Arch Dis Child. 1975 Aug;50(8):656-8. doi: 10.1136/adc.50.8.656.

DOI:10.1136/adc.50.8.656

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1545541/

Abstract

Measurement of urinary cyclic AMP (adenosine 3'5'-cyclic phosphate) and examination of calcium and phosphorus metabolism was carried out in two children with pseudohypoparathyroidism. In both patients infusion of parathyroid hormone failed to elicit any change in urinary cyclic AMP, while a dose-dependent increase in urinary cyclic AMP occurred in a normal control. The findings agree with concept of unresponsiveness of renal cortical tissue to parathyroid hormone in pseudohypoparathyroidism and provide further evidence that measurement of urinary cyclic AMP during parathyroid hormone infusion may be the method of choice in the diagnosis of this disease.

摘要

对两名假性甲状旁腺功能减退症患儿进行了尿中环磷酸腺苷（3',5'-环磷酸腺苷）的测定以及钙和磷代谢检查。在这两名患者中，静脉注射甲状旁腺激素均未能引起尿中环磷酸腺苷的任何变化，而在一名正常对照者中，尿中环磷酸腺苷出现了剂量依赖性增加。这些发现与假性甲状旁腺功能减退症中肾皮质组织对甲状旁腺激素无反应的概念相符，并进一步证明在静脉注射甲状旁腺激素期间测定尿中环磷酸腺苷可能是诊断该病的首选方法。

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Albright's hereditary osteodystrophy comprising pseudohypoparathyroidism and pseudo-pseudohypoparathyroidism. With a report of two cases representing the complete syndrome occurring in successive generations.奥尔布赖特遗传性骨营养不良，包括假性甲状旁腺功能减退和假假性甲状旁腺功能减退。报告两例代表连续两代出现的完整综合征的病例。

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Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate.3',5'-单磷酸腺苷和3',5'-单磷酸鸟苷的尿排泄量。

N Engl J Med. 1972 Jun 29;286(26):1382-7. doi: 10.1056/NEJM197206292862604.

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Pseudohypoparathyroidism. A disease of the second messenger (3',5'-cyclic AMP).假性甲状旁腺功能减退症。一种第二信使（3'，5'-环磷酸腺苷）相关疾病。

Arch Intern Med. 1972 Apr;129(4):633-7. doi: 10.1001/archinte.129.4.633.

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A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。

Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.

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Pseudohypoparathyroidism: defective excretion of 3',5'-AMP in response to parathyroid hormone.假性甲状旁腺功能减退症：对甲状旁腺激素反应时3',5'-AMP排泄缺陷。

J Clin Invest. 1969 Oct;48(10):1832-44. doi: 10.1172/JCI106149.

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