表观遗传学——基于DNA的环境之镜？
Epigenetics--DNA-based mirror of our environment?
作者信息
Cooney Craig A
机构信息
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
出版信息
Dis Markers. 2007;23(1-2):121-37. doi: 10.1155/2007/394034.
Epigenetics affects health, appearance and behavior and propagates mammalian phenotypes across generations. Nutrients, drugs and behavior can all direct changes in epigenetics. In at least some cases, these directed changes are propagated across generations. This range of influences on epigenetics suggests that epigenetics is highly interactive with the environment. Changes in the environment may regularly change epigenetics and influence our future responses to the environment. The current research challenge is to understand these influences and use them to direct epigenetics toward improved health and longevity.
表观遗传学影响健康、外貌和行为，并在代际间传递哺乳动物的表型。营养物质、药物和行为都能直接改变表观遗传学。至少在某些情况下，这些直接的改变会在代际间传递。表观遗传学受到的这一系列影响表明，它与环境具有高度的交互性。环境变化可能会经常改变表观遗传学，并影响我们未来对环境的反应。当前的研究挑战在于理解这些影响，并利用它们引导表观遗传学朝着改善健康和延长寿命的方向发展。
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