Niedzielska Iwona, Sypnilewski Daniel, Niedzielski Zbigniew
Department of Maxillofacial Surgery, Medical University of Silesia, Katowice, Poland.
Med Sci Monit. 2007 Mar;13(3):BR84-8.
Oral pathologies are divided by histochemical analysis. Molecular analysis is a future, and expensive, method, and in it, the role of gene BCL-2 may be of interest.
MATERIAL/METHODS: Forty-five patients with tumors of the oral cavity were enrolled. Biopsies were taken from the incision line, tumor section, and healthy tissue. A three-stage molecular analysis was carried out. BCL-2 expression was investigated depending on the site of the tissue material sample and the final histopathological result: hyperplasia (group I), neoplasm in situ malignancy (group II), and carcinoma (group III). Data from four subgroups of group I were also analyzed.
No statistically significant difference was demonstrated in BCL-2 expression among the four hyperplasia subgroups. However, statistically significant differences in BCL-2 expression were found among the three basic study groups (p=0.00002) and among the biopsy collection sites (p=0.002). The difference was the most pronounced between carcinoma and incision line, but was also noticeable between neoplasm in situ malignancies and incision line.
Monitoring BCL-2 expression may facilitate prognosis of the progress and ultimate severity of oral cavity hyperplasias.
口腔病理学通过组织化学分析进行划分。分子分析是一种未来的、昂贵的方法，其中基因BCL - 2的作用可能值得关注。
材料/方法：纳入45例口腔肿瘤患者。从切口线、肿瘤切片和健康组织处获取活检样本。进行了三阶段分子分析。根据组织材料样本的部位和最终组织病理学结果研究BCL - 2表达情况：增生（I组）、原位恶性肿瘤（II组）和癌（III组）。还分析了I组四个亚组的数据。
四个增生亚组之间的BCL - 2表达无统计学显著差异。然而，在三个基础研究组之间（p = 0.00002）以及活检采集部位之间（p = 0.002）发现了BCL - 2表达的统计学显著差异。癌与切口线之间的差异最为明显，原位恶性肿瘤与切口线之间的差异也较为显著。
监测BCL - 2表达可能有助于预测口腔增生的进展和最终严重程度。
