Sahni Charandeep S, Desai Sangeeta B
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India.
Leuk Lymphoma. 2007 Jan;48(1):122-33. doi: 10.1080/10428190601043351.
The frequency of various subtypes of non-Hodgkin's lymphoma (NHL) differs in various regions worldwide. We studied distribution of various subtypes of NHL by using WHO classification of lymphoid neoplasms (2000), immunophenotyping and clinicopathologic characteristics of various histologic subtypes in 935 cases. B- and T-cell NHL constituted 79.3% and 18.8% of cases. Diffuse large B-cell lymphoma (DLBL) was the most common subtype (50.2%). A lower frequency of follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma (MCL) was noted compared to that observed in the developed countries, whereas a lower frequency of peripheral T-cell lymphoma - not otherwise specified (PTCL-NOS) and extranodal NK/T-cell lymphoma was seen compared to that in the other Asian countries. A higher frequency of DLBL and precursor T-lymphoblastic leukemia/lymphoma was noted. Extranodal and bone marrow involvement in MCL and PTCL-NOS was less frequent. Anaplastic variant of DLBL was noted in 21.5% of all DLBLs. Null/T-cell anaplastic large cell lymphoma presented in the older age.
非霍奇金淋巴瘤（NHL）各亚型的发病率在全球不同地区存在差异。我们采用世界卫生组织淋巴系统肿瘤分类（2000年版），对935例NHL患者的免疫表型及各组织学亚型的临床病理特征进行分析，以研究NHL各亚型的分布情况。B细胞NHL和T细胞NHL分别占病例总数的79.3%和18.8%。弥漫性大B细胞淋巴瘤（DLBL）是最常见的亚型（50.2%）。与发达国家相比，滤泡性淋巴瘤、边缘区淋巴瘤和套细胞淋巴瘤（MCL）的发病率较低；与其他亚洲国家相比，外周T细胞淋巴瘤，非特殊类型（PTCL-NOS）和结外NK/T细胞淋巴瘤的发病率较低。DLBL和前体T淋巴细胞白血病/淋巴瘤的发病率较高。MCL和PTCL-NOS的结外及骨髓受累情况较少见。在所有DLBL中，21.5%为DLBL间变性变异型。Null/T细胞间变性大细胞淋巴瘤多见于老年患者。
