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一位骨髓增生异常综合征合并Sweet综合征患者成功接受减低强度干细胞移植。

Successful reduced-intensity stem cell transplantation in a patient with myelodysplastic syndrome combined with Sweet's syndrome.

作者信息

Ashida Takashi, Mayama Takashi, Higashishiba Masaki, Kawanishi Kazunobu, Miyatake Junichi, Tatsumi Yoichi, Kanamaru Akihisa

机构信息

Division of Hematology, Department of Internal Medicine, Kinki University School of Medicine, 377-2, Ohonohigashi, Osakasayama, Osaka, Japan.

出版信息

Hematology. 2006 Jun;11(3):179-81. doi: 10.1080/10245330600667492.

DOI:10.1080/10245330600667492
PMID:17325958
Abstract

A 53-year-old male with myelodysplastic syndrome developed Sweet's syndrome extensively over his left iliac and inguinal regions that was refractory to standard treatment with corticosteroids and chemotherapy, received a stem cell transplant from an HLA-matched unrelated donor, conditioned by reduced-intensity regimen. The patient achieved complete hematological remission, and the cutaneous lesions improved gradually and then disappeared completely despite the patient receiving granulocyte colony-stimulating factor after transplantation and developing acute graft-versus-host disease.

摘要

一名53岁患有骨髓增生异常综合征的男性,其左髂部和腹股沟区广泛出现斯威特综合征,对皮质类固醇和化疗的标准治疗无效,接受了来自人类白细胞抗原匹配的无关供体的干细胞移植,采用减低强度预处理方案。患者实现了完全血液学缓解,皮肤病变逐渐改善,尽管移植后接受了粒细胞集落刺激因子并发生了急性移植物抗宿主病,但皮肤病变最终完全消失。

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Successful reduced-intensity stem cell transplantation in a patient with myelodysplastic syndrome combined with Sweet's syndrome.一位骨髓增生异常综合征合并Sweet综合征患者成功接受减低强度干细胞移植。
Hematology. 2006 Jun;11(3):179-81. doi: 10.1080/10245330600667492.
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Allogeneic stem cell transplantation after a fludarabine/busulfan-based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.在患有骨髓增生异常综合征或继发性急性髓系白血病的患者中,基于氟达拉滨/白消安的减低强度预处理后进行异基因干细胞移植。
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A fludarabine-based dose-reduced conditioning regimen followed by allogeneic stem cell transplantation from related or unrelated donors in patients with myelodysplastic syndrome.对于骨髓增生异常综合征患者,采用基于氟达拉滨的剂量降低预处理方案,随后接受来自相关或无关供体的异基因干细胞移植。
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Intermediate-dose busulfan and cyclophosphamide as a conditioning regimen for bone marrow transplantation in a case of Fanconi anemia in myelodysplastic transformation.中等剂量白消安和环磷酰胺作为范可尼贫血骨髓增生异常转化病例骨髓移植的预处理方案
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Busulfan dose intensity and outcomes in reduced-intensity allogeneic peripheral blood stem cell transplantation for myelodysplastic syndrome or acute myeloid leukemia.马利兰剂量强度与骨髓增生异常综合征或急性髓系白血病患者行减低强度异基因外周血造血干细胞移植的结局。
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Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia.慢性髓性白血病患者接受匹配无关供者骨髓移植14个月后发生供者细胞来源的急性髓性白血病。
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Complete remission of MDS RAEB following immunosuppressive treatment in a patient with Sweet's syndrome.
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Allogeneic peripheral blood stem cell transplantation using a fludarabine-based low intensity conditioning regimen for malignant lymphoma.采用基于氟达拉滨的低强度预处理方案进行异基因外周血干细胞移植治疗恶性淋巴瘤。
Bone Marrow Transplant. 2000 May;25(10):1021-8. doi: 10.1038/sj.bmt.1702392.
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Prospective phase II trial to evaluate the complications and kinetics of chimerism induction following allogeneic hematopoietic stem cell transplantation with fludarabine and busulfan.一项前瞻性II期试验,旨在评估氟达拉滨和白消安进行异基因造血干细胞移植后嵌合状态诱导的并发症及动力学。
Am J Hematol. 2007 Oct;82(10):873-80. doi: 10.1002/ajh.20977.
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Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: chronic graft-versus-host disease is the strongest factor improving survival.减低强度预处理异基因造血移植后高危急性髓系白血病和骨髓增生异常综合征的持续缓解:慢性移植物抗宿主病是改善生存的最强因素。
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