Madur Bhulaxmi, Shet Tanuja, Chinoy Roshni
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India.
Acta Cytol. 2007 Jan-Feb;51(1):25-32. doi: 10.1159/000325678.
To examine the observation that some mucinous carcinomas have a micropapillary pattern and are mucinous variants of the highly angioinvasive infiltrating micropapillary carcinomas (IMPC).
We evaluated cytologic findings of 13 IMPC and 55 mucinous carcinomas for comparative features.
In mucinous carcinomas, 37 of 50 (74%) had a micropapillary pattern. This group included 27 cases with pure mucinous micropapillary morphology (MUMPC), 8 MUMPC associated with a ductal carcinoma of the IMPC type (MUIDC) and 2 cases of mixed mucinous carcinomas with an MUMPC and a solid variant ofpapillary carcinoma (SVPC) component. On cytology both IMPC and mucinous carcinomas with micropapillary pattern demonstrated the micropapillary pattern, that is, angulated clusters or abortive papillae and ball-like clusters. However, the IMPC smears revealed numerous singly scattered tumor cells and larger fragments with shrub-like branching and the MUMPC had psammoma bodies. The mixed MUMPC and SVPC showed the classic cytologic features of MUMPC admixed with abundant singly dispersed tumor cells in the background representing the SVPC component.
Although IMPC and the MUMPC share the micropapillary pattern on histologic examination, mucin alters the appearances in aspirates. Recognition of this morphologic spectrum will help in understanding the behavior of these tumors.
研究某些黏液性癌具有微乳头模式且是高度血管侵袭性浸润性微乳头癌（IMPC）的黏液性变体这一现象。
我们评估了13例IMPC和55例黏液性癌的细胞学发现以进行比较。
在黏液性癌中，50例中有37例（74%）具有微乳头模式。该组包括27例纯黏液性微乳头形态（MUMPC）、8例与IMPC型导管癌相关的MUMPC（MUIDC）以及2例具有MUMPC和实性乳头状癌（SVPC）成分的混合性黏液性癌。在细胞学上，IMPC和具有微乳头模式的黏液性癌均显示出微乳头模式，即角状细胞簇或发育不全的乳头及球状细胞簇。然而，IMPC涂片显示有大量单个散在的肿瘤细胞和具有树枝状分支的较大碎片，而MUMPC有砂粒体。混合性MUMPC和SVPC显示出MUMPC的典型细胞学特征，并在背景中混有大量单个分散的肿瘤细胞，代表SVPC成分。
尽管IMPC和MUMPC在组织学检查中都有微乳头模式，但黏液会改变抽吸物中的表现。认识到这种形态学谱将有助于理解这些肿瘤的行为。
