（芳氧基乙酰氨基）苯甲酸类似物：一类新型的缺氧诱导因子-1抑制剂。
(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
作者信息
Lee Kyeong, Lee Jeong Hyung, Boovanahalli Shanthaveerappa K, Jin Yinglan, Lee Mijeoung, Jin Xuejun, Kim Jin Hwan, Hong Young-Soo, Lee Jung Joon
机构信息
Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, 305-806.
出版信息
J Med Chem. 2007 Apr 5;50(7):1675-84. doi: 10.1021/jm0610292. Epub 2007 Mar 1.
Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.
使用依赖于缺氧反应元件（HRE）的报告基因检测法在筛选过程中发现的一种化合物的结构修饰，揭示了一类新型的缺氧诱导因子-1（HIF-1）抑制剂，这类抑制剂在人肝癌Hep3B细胞的缺氧条件下能有效抑制HIF-1α蛋白的积累及其靶基因的表达。
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