Burt R W, Witt R M, Cikrit D F, Reddy R V
Department of Radiology, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202.
Radiology. 1992 Feb;182(2):461-6. doi: 10.1148/radiology.182.2.1732965.
Sixty patients were studied for carotid artery disease and were further evaluated with hexamethyl-propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) both at baseline (with the patient resting) and after administration of acetazolamide (ACZ). Of these 60 patients, 58 (97%) had symptoms and 49 (82%) had stenoses greater than 70% in at least one internal carotid vessel. Nine patients (15%) had symmetric findings on baseline examinations and at SPECT with ACZ. Thirty-two patients (53%) had asymmetric findings on baseline, but in 24 of these patients (75%) additional lesions were observed after ACZ administration. Nineteen patients (32%) had asymmetric findings only after ACZ was administered. HMPAO SPECT with ACZ allows detection of diminished cerebral perfusion reserve that is not found when HMPAO SPECT is performed with the patient at rest. This procedure helps provide an objective evaluation of the hemodynamic effects of carotid stenosis.
对60例患有颈动脉疾病的患者进行了研究，并在基线时（患者静息状态）和给予乙酰唑胺（ACZ）后，使用六甲基丙烯胺肟（HMPAO）单光子发射计算机断层扫描（SPECT）进行了进一步评估。在这60例患者中，58例（97%）有症状，49例（82%）至少有一根颈内血管狭窄超过70%。9例患者（15%）在基线检查和ACZ SPECT检查时有对称表现。32例患者（53%）在基线时有不对称表现，但其中24例患者（75%）在给予ACZ后观察到额外病变。19例患者（32%）仅在给予ACZ后有不对称表现。ACZ的HMPAO SPECT能够检测到静息状态下进行HMPAO SPECT时未发现的脑灌注储备减少。该程序有助于对颈动脉狭窄的血流动力学效应进行客观评估。
