Outwater E, Schnall M D, Braitman L E, Dinsmore B J, Kressel H Y
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Radiology. 1992 Feb;182(2):535-40. doi: 10.1148/radiology.182.2.1732976.
The authors evaluated the technique of magnetization transfer to determine if it could enable distinction of benign from malignant liver lesions. Thirteen patients with 27 hemangiomas or cysts and 13 patients with 31 malignant liver lesions underwent magnetic resonance imaging. Hepatic malignancies demonstrated magnetization transfer similar to that of the liver. However, hemangiomas and cysts showed significantly less magnetization transfer than malignant liver lesions. Gradient-recalled-echo imaging with the off-resonance saturation pulse showed increased lesion contrast compared with the liver for hemangiomas and cysts but not for malignancies. On the basis of signal intensity measurements alone (ie, ignoring morphologic criteria), the magnetization transfer studies showed an area under the receiver operating characteristic curve of 0.96 for distinguishing benign from malignant liver lesions. Though the separation of these two groups was imperfect, it was comparable with that achieved with qualitative analysis of signal intensity ratios at spin-echo imaging.
作者评估了磁化传递技术，以确定其是否能够区分肝脏良性病变和恶性病变。13例患有27个血管瘤或囊肿的患者以及13例患有31个肝脏恶性病变的患者接受了磁共振成像检查。肝脏恶性肿瘤显示出与肝脏相似的磁化传递。然而，血管瘤和囊肿的磁化传递明显低于肝脏恶性病变。与肝脏相比，使用失谐饱和脉冲的梯度回波成像显示血管瘤和囊肿的病变对比度增加，但恶性肿瘤则不然。仅基于信号强度测量（即忽略形态学标准），磁化传递研究显示，区分肝脏良性病变和恶性病变的受试者工作特征曲线下面积为0.96。虽然这两组的区分并不完美，但与自旋回波成像中信号强度比的定性分析所达到的区分效果相当。
