心脏移植中的信号平均心电图。急性同种异体移植排斥反应的一种非侵入性标志物。

The signal-averaged electrocardiogram in cardiac transplantation. A noninvasive marker of acute allograft rejection.

作者信息

Valentino V A, Ventura H O, Abi-Samra F M, Van Meter C H, Price H L

机构信息

Department of Internal Medicine, Ochsner Medical Instituations, New Orleans, Louisiana 70121.

出版信息

Transplantation. 1992 Jan;53(1):124-7. doi: 10.1097/00007890-199201000-00024.

DOI:10.1097/00007890-199201000-00024

PMID:1733059

Abstract

Cardiac allograft rejection represents a major cause of morbidity and mortality in transplanted patients. Noninvasive markers of rejection have been sought, though transvenous endomyocardial biopsy remains the "gold standard" for the diagnosis of rejection. Sixty-one signal-averaged electrocardiograms (five in patients with rejection and 56 in patients without rejection) were obtained on 41 patients and prospectively analyzed in frequency domain via fast Fourier transform (FFT). Patients with acute allograft rejection demonstrate a significant increase in the high-frequency components of the QRS complex upon FFT analysis (QRS area ratio 203 +/- 57 vs. 66 +/- 10, P = 0.0007) compared with patients without rejection. Thus, frequency domain analysis may be a useful noninvasive marker of acute cardiac allograft rejection.

摘要

心脏移植排斥反应是移植患者发病和死亡的主要原因。人们一直在寻找排斥反应的非侵入性标志物，不过经静脉心内膜活检仍是诊断排斥反应的“金标准”。对41例患者进行了61次信号平均心电图检查（5例有排斥反应的患者和56例无排斥反应的患者），并通过快速傅里叶变换（FFT）在频域进行前瞻性分析。与无排斥反应的患者相比，急性移植排斥反应患者经FFT分析后QRS波群高频成分显著增加（QRS面积比203±57对66±10，P = 0.0007）。因此，频域分析可能是急性心脏移植排斥反应有用的非侵入性标志物。