Foral Pamela A, Ineck Joseph R, Nystrom Kelly K
Alegent Health, Bergan Mercy Medical Center, and Creighton University, Omaha, NE, USA.
South Med J. 2007 Feb;100(2):212-4. doi: 10.1097/01.smj.0000242876.45747.0a.
Oxycodone and oxycodone-containing analgesics are often used for the relief of pain. In the presence of renal dysfunction, the half-life of oxycodone and metabolites can be prolonged. We describe the case of a 41-year-old chronic hemodialysis patient who received multiple doses of oxycodone/acetaminophen resulting in accumulation of the medication and consequent lethargy, hypotension and respiratory depression. These adverse effects were reversed with multiple bolus doses of naloxone, followed by a continuous infusion administered for 45 hours. Utilizing the Naranjo probability scale, the patient had a "probable" adverse drug reaction to the oxycodone. Oxycodone should be used with caution in patients with chronic renal failure.
羟考酮及含羟考酮的镇痛药常用于缓解疼痛。在肾功能不全的情况下，羟考酮及其代谢产物的半衰期可能会延长。我们描述了一名41岁慢性血液透析患者的病例，该患者多次服用羟考酮/对乙酰氨基酚后导致药物蓄积，进而出现嗜睡、低血压和呼吸抑制。通过多次静脉推注纳洛酮，随后持续输注45小时，这些不良反应得到了逆转。根据纳兰霍概率量表，该患者对羟考酮有“很可能”的药物不良反应。慢性肾衰竭患者应谨慎使用羟考酮。
