载脂蛋白B信使核糖核酸编辑酶催化多肽样3G：在暴露于HIV的血清阴性个体对HIV的抗性中可能发挥的作用。
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals.
作者信息
Biasin Mara, Piacentini Luca, Lo Caputo Sergio, Kanari Yasuyoshi, Magri Giuliana, Trabattoni Daria, Naddeo Valentina, Lopalco Lucia, Clivio Alberto, Cesana Eugenio, Fasano Francesca, Bergamaschi Cristina, Mazzotta Francesco, Miyazawa Masaaki, Clerici Mario
机构信息
Department of Immunology, Dipartimento di Scienze Precliniche Laboratorio Interdisciplinare Tecnologie Avanzate Vialba, Milano University Medical School, Milano, Italy.
出版信息
J Infect Dis. 2007 Apr 1;195(7):960-4. doi: 10.1086/511988. Epub 2007 Feb 16.
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)--mainly CD14(+) cells--and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.
载脂蛋白B信使核糖核酸编辑酶催化多肽样3G（APOBEC3G）是一种人类胞苷脱氨酶，是HIV复制的有效抑制剂。为了探究该蛋白在调节体内对HIV感染易感性方面的可能作用，我们分析了HIV暴露血清阴性个体、HIV血清阳性患者及健康对照者中APOBEC3G的表达情况。结果显示，APOBEC3G的表达在HIV暴露血清阴性个体的外周血单个核细胞（PBMC）——主要是CD14(+)细胞——及宫颈组织中显著增加。较高的APOBEC3G表达与PBMC对HIV-1(Ba-L) R5毒株体外感染的易感性降低相关。APOBEC3G在调节体内对性传播HIV感染的易感性方面可能具有重要作用。
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