来曲唑与醋酸炔诺酮治疗直肠阴道内异症
Letrozole and norethisterone acetate in rectovaginal endometriosis.
作者信息
Remorgida Valentino, Abbamonte Helena Luiza, Ragni Nicola, Fulcheri Ezio, Ferrero Simone
机构信息
Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Genoa, Italy.
出版信息
Fertil Steril. 2007 Sep;88(3):724-6. doi: 10.1016/j.fertnstert.2006.12.027. Epub 2007 Feb 28.
This open-label prospective study evaluated the efficacy of letrozole (2.5 mg/day) combined with norethisterone acetate (2.5 mg/day) in the treatment of pain symptoms related to the presence of rectovaginal endometriosis. The treatment significantly and quickly decreased the intensity of symptoms, but pain recurred at 3-month follow-up; five women underwent surgery during the follow-up, and histologic examination of rectovaginal nodules revealed the presence of active endometriotic lesions.
这项开放标签的前瞻性研究评估了来曲唑（2.5毫克/天）联合醋酸炔诺酮（2.5毫克/天）治疗与直肠阴道子宫内膜异位症相关疼痛症状的疗效。治疗显著且迅速地降低了症状强度，但在3个月随访时疼痛复发；5名女性在随访期间接受了手术，直肠阴道结节的组织学检查显示存在活跃的子宫内膜异位病变。
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