台湾中部1型糖尿病患儿的特应性患病率

Prevalence of atopy in children with type 1 diabetes mellitus in central Taiwan.

作者信息

Tzeng Shiou Tzong, Hsu San Ging, Fu Lin Shien, Chi Chin Shiang

机构信息

Division of Immunology and Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.

出版信息

J Microbiol Immunol Infect. 2007 Feb;40(1):74-8.

PMID:17332911

Abstract

BACKGROUND AND PURPOSE

Atopic diseases, including asthma, eczema and allergic rhinitis, are characterized by a chronic inflammatory reaction mediated by T helper 2 (Th2) cells, while type 1 diabetes mellitus (T1D) is mediated by T helper 1 (Th1) cells. The 'balance' between Th1 and Th2 cells appears to be vitally important. Hence, it is a plausible hypothesis that the prevalence in Th2-mediated disease would be lower in patients with Th1-mediated disease. The aim of this study was to compare the prevalence of atopic diseases between children with T1D and age-matched controls, and investigate possible factors that influence the prevalence of atopic disease.

METHODS

Parents of children with T1D in Taichung Veterans General Hospital were requested by pediatricians to complete the International Study of Asthma and Allergies in Childhood questionnaire on the prevalence of atopic diseases. Responses were compared with an age-matched control group.

RESULTS

Questionnaires were evaluated from 100 T1D patients and 194 controls. After age-matching, the questionnaires of 54 T1D patients were included. Symptoms of asthma, allergic rhinitis and eczema were reported less often in the group of children with T1D compared with the control group (wheeze with exercise, p=0.044; nasal symptoms with itching eyes in the past 12 months, p=0.048; nasal allergy ever, p=0.038; skin rash in the past 12 months, p=0.044). In addition, the proportion of T1D patients with any asthmatic symptom (such as wheezing once in life, wheezing in the past 12 months, wheezing with exercise and dry cough at night in the past 12 months) was significantly lower than in controls (20.4% vs 36.6%, p=0.036).

CONCLUSIONS

These results indicate that patients with T1D have a lower prevalence of atopic symptoms, especially asthma, which is consistent with the Th1/Th2 polarization concept. Environmental factors are another direct influence on the development of atopy in T1D patients.

摘要

背景与目的

特应性疾病，包括哮喘、湿疹和过敏性鼻炎，其特征为辅助性T细胞2（Th2）介导的慢性炎症反应，而1型糖尿病（T1D）由辅助性T细胞1（Th1）介导。Th1和Th2细胞之间的“平衡”似乎至关重要。因此，有一个看似合理的假设，即Th1介导疾病的患者中Th2介导疾病的患病率会更低。本研究的目的是比较T1D患儿与年龄匹配的对照组中特应性疾病的患病率，并调查影响特应性疾病患病率的可能因素。

方法

台中荣民总医院的儿科医生要求T1D患儿的家长填写关于特应性疾病患病率的儿童哮喘和过敏国际研究问卷。将回答与年龄匹配的对照组进行比较。

结果

对100名T1D患者和194名对照组的问卷进行了评估。年龄匹配后，纳入了54名T1D患者的问卷。与对照组相比，T1D患儿组中哮喘、过敏性鼻炎和湿疹症状的报告频率较低（运动性喘息，p = 0.044；过去12个月内伴有眼痒的鼻部症状，p = 0.048；曾患鼻过敏，p = 0.038；过去12个月内皮疹，p = 较T1D患者中出现任何哮喘症状（如一生中喘息一次、过去12个月内喘息、运动性喘息和过去12个月内夜间干咳）的比例显著低于对照组（20.4%对36.6%，p = 0.036）。