Li Xinsong, Zou Jun, Zhu Guohua, Qi Xinsheng, Pu Yuepu
Biomaterials and Drug Delivery Laboratories, Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210018, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Feb;24(1):81-6.
Abstract Poly-l-lactide/beta-tricalcium phosphate (PLLA/betaTCP) composite was obtained by combining ground beta-TCP with PLLA, and absorbable rods were prepared by injection moulding. Degradations of the rods were investigated by scanning electron microscope (SEM), mass loss, molecular weight and bending strength changes. At the beginning of in vivo degradation of the rods, the molecular weight of PLLA decreases sharply with the less mass losses of the rods. As in vivo degradation progress, the surfaces of the rods changed roughly, while micropores and fine groove were observed in the inner part of the rods. The bending strength of composite rods decreased from 151 MPa to 106 MPa after in vivo degradation of 12 weeks. Tissue test reveal that PLLA/beta-TCP composite has good tissue compatibility compared with PLLA.
摘要 通过将研磨后的β-磷酸三钙与聚左旋乳酸（PLLA）结合制备了聚左旋乳酸/β-磷酸三钙（PLLA/β-TCP）复合材料，并通过注射成型制备了可吸收棒材。通过扫描电子显微镜（SEM）、质量损失、分子量和弯曲强度变化研究了棒材的降解情况。在棒材体内降解开始时，PLLA的分子量急剧下降，而棒材的质量损失较小。随着体内降解过程的进行，棒材表面变得粗糙，而在棒材内部观察到微孔和细槽。体内降解12周后，复合棒材的弯曲强度从151MPa降至106MPa。组织测试表明，与PLLA相比，PLLA/β-TCP复合材料具有良好的组织相容性。
