Geiger Margarethe
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria.
Thromb Haemost. 2007 Mar;97(3):343-7.
Human protein C inhibitor (PCI), a serpin-type protease inhibitor originally described as an inhibitor of activated protein C, has broad protease reactivity. In addition to its activities within the blood clotting and fibrinolytic cascades, it seems to participate in several biological processes including reproduction and tumor growth. This review summarizes the current understanding of PCI function, regulation, and potential biological role.
人蛋白C抑制剂（PCI）是一种丝氨酸蛋白酶抑制剂，最初被描述为活化蛋白C的抑制剂，具有广泛的蛋白酶反应活性。除了在凝血和纤溶级联反应中的活性外，它似乎还参与包括生殖和肿瘤生长在内的多种生物学过程。本文综述了目前对PCI功能、调节及其潜在生物学作用的认识。
