Costa Marilisa Nano, Marcondes Ana Maria, Sakano Eulalia, Kara-José Newton
State University of Campinas, Campinas, SP, Brasil.
Clinics (Sao Paulo). 2007 Feb;62(1):41-6. doi: 10.1590/s1807-59322007000100007.
To study, through endoscopy, the postoperative structural changes of the intranasal ostium following external dacryocystorhinostomy and to evaluate the influence of saline solution and 5-fluorouracil.
Fifty patients were distributed into the following groups: Group SS-dacryocystorhinostomy and an injection of saline solution during surgery (13 patients); Group 5--FU1-dacryocystorhinostomy and an injection of 5 fluorouracil during surgery (17 patients); Group C--dacryocystorhinostomy only (11 patients); Group 5--FU3-dacryocystorhinostomy and 3 injections, 1 during surgery and 1 on the third and fifth postsurgical days (9 patients).
Pair-wise group comparisons using the nonparametric Mann-Whitney test revealed that there was a significant reduction of the ostium area only in Group 5-FU1 vs. Group SS on the 60th postoperative day (P <.01); however, a comparative study among the 4 groups using the Kruskal-Wallis test showed no significant changes in the ostium area on the 60th postoperative day. The ostium area within groups at the 30th vs 60th postoperative day was significantly reduced for Group C (P < .05; Mann-Whitney test); no significant changes were found for the other groups.
These results suggest that the use of 5-fluorouracil in external dacryocystorhinostomy does not significantly influence the final size of the surgical fistula as determined 2 months postsurgery.
通过内窥镜研究外路泪囊鼻腔吻合术后鼻内开口的术后结构变化，并评估盐溶液和5-氟尿嘧啶的影响。
50例患者分为以下几组：SS组——泪囊鼻腔吻合术并在手术期间注射盐溶液（13例患者）；5-FU1组——泪囊鼻腔吻合术并在手术期间注射5-氟尿嘧啶（17例患者）；C组——仅行泪囊鼻腔吻合术（11例患者）；5-FU3组——泪囊鼻腔吻合术并注射3次，1次在手术期间，1次在术后第3天和第5天（9例患者）。
使用非参数曼-惠特尼检验进行组间两两比较显示，仅在术后第60天，5-FU1组与SS组相比鼻内开口面积有显著减小（P <.01）；然而，使用克鲁斯卡尔-沃利斯检验对4组进行的比较研究显示，术后第60天鼻内开口面积无显著变化。术后第30天与第60天相比，C组组内鼻内开口面积显著减小（P <.05；曼-惠特尼检验）；其他组未发现显著变化。
这些结果表明，在外路泪囊鼻腔吻合术中使用5-氟尿嘧啶对术后2个月确定的手术瘘管最终大小没有显著影响。
