Nakagawa Yasunori, Ichii Yoko, Saeki Yasuhiro, Kodaka Masanobu, Suzuki Kenshi, Kishino Satoshi
Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan.
J Infect Chemother. 2007 Feb;13(1):39-45. doi: 10.1007/s10156-006-0496-1. Epub 2007 Feb 26.
In 20 patients with hematologic malignancies, we measured the plasma concentration of micafungin (MCFG) by high-performance liquid chromatography after drip infusion of MCFG, at 150 mg/day over a 1-h period, and we analyzed the results in relation to the patients' laboratory parameters of liver and kidney function. Measurement of the plasma concentration was performed at the end of the initial administration of MCFG, 5 to 6 h after the start of the initial administration, immediately before the second dosing, immediately before the fourth dosing, and at the end of the fourth dosing. The plasma concentration of MCFG was correlated with the doses of MCFG per kilogram body weight (P = 0.0008-0.0036). The peak after the initial administration was 2.6 times higher than the trough value after the initial administration. The steady-state trough value was 1.2 times higher than the trough value after the initial administration. There was no correlation between the liver/kidney function parameters and the plasma concentration of MCFG. These results suggest that there was a good correlation between the plasma concentration of MCFG and the dose of MCFG per kilogram body weight, and that MCFG can be administered safely to patients with liver or kidney dysfunction without adjusting the dose.
在20例血液系统恶性肿瘤患者中，我们通过高效液相色谱法测定了米卡芬净（MCFG）静脉滴注1小时、每日剂量150 mg后血浆中MCFG的浓度，并分析了其结果与患者肝肾功能实验室参数的关系。在MCFG首次给药结束时、首次给药开始后5至6小时、第二次给药前即刻、第四次给药前即刻以及第四次给药结束时进行血浆浓度测定。MCFG的血浆浓度与每千克体重的MCFG剂量相关（P = 0.0008 - 0.0036）。首次给药后的峰值比首次给药后的谷值高2.6倍。稳态谷值比首次给药后的谷值高1.2倍。肝/肾功能参数与MCFG的血浆浓度之间无相关性。这些结果表明，MCFG的血浆浓度与每千克体重的MCFG剂量之间具有良好的相关性，并且在不调整剂量的情况下，MCFG可以安全地用于肝或肾功能不全的患者。
