Higuchi Wataru, Isobe Hirokazu, Iwao Yasuhisa, Dohmae Soshi, Saito Kohei, Takano Tomomi, Otsuka Taketo, Baranovich Tatiana, Endo Chiho, Suzuki Nobuaki, Tomiyama Yasuyuki, Yamamoto Tatsuo
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibanchou, Asahimachidori, Niigata 951-8510, Japan.
J Infect Chemother. 2007 Feb;13(1):63-6. doi: 10.1007/s10156-006-0492-5. Epub 2007 Feb 26.
Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolated from the nasal mucosa of medical students were examined for susceptibility to 16 antimicrobial agents. No methicillin-resistant S. aureus (MRSA) was isolated, while MRCNS was present in 23.5% of the medical students. CNS exhibited significantly more resistance to antimicrobial agents such as gentamicin, in addition to oxacillin, compared to S. aureus, and 13.1% of the CNS strains (mostly MRCNS) were multidrug-resistant (to five or more drugs). In contrast, ampicillin resistance was higher in S. aureus. The rate of hospitalization or of taking an antimicrobial agent within the past 1 year was lower in CNS+ students than in S. aureus+ students. The data suggest that CNS could serve as a reservoir of drug resistance by persistent colonization in the nasal mucosa. In this study, MRCNS with multidrug resistance was found in medical students. More attention should be given to nasal MRCNS in medical students as a possible spreader in hospitals.
对从医学生鼻腔黏膜分离出的金黄色葡萄球菌和凝固酶阴性葡萄球菌（CNS）进行了16种抗菌药物的敏感性检测。未分离出耐甲氧西林金黄色葡萄球菌（MRSA），而耐甲氧西林CNS存在于23.5%的医学生中。与金黄色葡萄球菌相比，CNS除对苯唑西林外，对庆大霉素等抗菌药物的耐药性明显更高，并且13.1%的CNS菌株（大多为耐甲氧西林CNS）对多种药物耐药（对五种或更多药物耐药）。相比之下，金黄色葡萄球菌对氨苄西林的耐药性更高。CNS阳性学生在过去1年内的住院率或服用抗菌药物的比例低于金黄色葡萄球菌阳性学生。数据表明，CNS可能通过在鼻腔黏膜持续定植而成为耐药性的储存库。在本研究中，在医学生中发现了具有多重耐药性的耐甲氧西林CNS。应更加关注医学生鼻腔中的耐甲氧西林CNS，因为其可能是医院内的传播源。
