右旋吗啡通过激活大鼠体内的σ1受体减弱吗啡诱导的条件性位置偏爱。
dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma(1) receptor activation in the rat.
作者信息
Wu Hsiang-en, Schwasinger Emma T, Terashvili Maia, Tseng Leon F
机构信息
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
出版信息
Eur J Pharmacol. 2007 May 21;562(3):221-6. doi: 10.1016/j.ejphar.2007.01.083. Epub 2007 Feb 8.
An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to 3 microg/kg given subcutaneously dose-dependently attenuated the morphine-produced conditioned place preference. However, dextro-morphine at a higher dose 100 microg/kg did not affect the morphine-produced conditioned place preference. Thus, dextro-morphine pretreatment induces a U-shaped dose-response curve for attenuating the morphine-produced conditioned place preference. The attenuation of the morphine-produced conditioned place preference was reversed by the pretreatment with the sigma(1) receptor antagonist BD1047 (N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. dextro-Morphine or BD1047 given alone did not affect the baseline place conditioning. It is concluded that dextro-morphine attenuated the morphine-produced conditioned place preference via the sigma(1) receptor activation.
采用无偏倚条件性位置偏爱范式评估右吗啡对雄性CD大鼠吗啡诱导奖赏效应的影响。腹腔注射硫酸吗啡（1 - 10 mg/kg）可剂量依赖性地产生条件性位置偏爱。皮下注射剂量为0.1至3 μg/kg的右吗啡预处理可剂量依赖性地减弱吗啡诱导的条件性位置偏爱。然而，100 μg/kg的高剂量右吗啡并不影响吗啡诱导的条件性位置偏爱。因此，右吗啡预处理诱导出一条U形剂量反应曲线来减弱吗啡诱导的条件性位置偏爱。吗啡诱导的条件性位置偏爱减弱可被σ1受体拮抗剂BD1047（N-[2-(3,4-二氯苯基)乙基]-N-甲基-2-(二甲基氨基)乙胺二氢溴化物）预处理逆转。单独给予右吗啡或BD1047不影响基线位置条件反射。结论是右吗啡通过激活σ1受体减弱吗啡诱导的条件性位置偏爱。
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