酗酒家族史会影响纳曲酮诱导的饮酒量减少。
Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking.
作者信息
Krishnan-Sarin Suchitra, Krystal John H, Shi Julia, Pittman Brian, O'Malley Stephanie S
机构信息
Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA.
出版信息
Biol Psychiatry. 2007 Sep 15;62(6):694-7. doi: 10.1016/j.biopsych.2006.11.018. Epub 2007 Mar 6.
BACKGROUND
The purpose of this study was to examine the interactive effects of family history of alcoholism (FH+, FH-) and naltrexone dose (0, 50, 100 mg/day) on alcohol drinking.
METHODS
Ninety-two, non-treatment-seeking alcohol-dependent participants received naltrexone daily for 6 days. On the 6th day, they participated in a laboratory paradigm involving exposure to a priming dose of alcohol followed by a 2-hour drinking period in which they made choices between consuming alcoholic drinks and receiving money.
RESULTS
Total number of drinks consumed during the drinking period was significantly decreased by the 100-mg dose of naltrexone in FH+ drinkers. Secondary analyses in male drinkers (n = 70) indicated that 100 mg of naltrexone significantly decreased drinking in FH+ participants and increased drinking in FH- drinkers.
CONCLUSIONS
These results suggest that family history of alcoholism might be a significant clinical predictor of response to naltrexone and that FH+ men are more likely to benefit from naltrexone therapy for alcohol drinking.
背景
本研究旨在探讨酒精中毒家族史（FH +，FH -）和纳曲酮剂量（0、50、100毫克/天）对饮酒的交互作用。
方法
92名未寻求治疗的酒精依赖参与者每天服用纳曲酮，持续6天。在第6天，他们参与了一个实验室范式，包括接触一次酒精启动剂量，随后是一个2小时的饮酒期，在此期间他们要在饮用酒精饮料和获得金钱之间做出选择。
结果
在FH +饮酒者中，100毫克剂量的纳曲酮显著减少了饮酒期饮用的饮料总数。对男性饮酒者（n = 70）的二次分析表明，100毫克纳曲酮显著减少了FH +参与者的饮酒量，并增加了FH -饮酒者的饮酒量。
结论
这些结果表明，酒精中毒家族史可能是对纳曲酮反应的一个重要临床预测指标，并且FH +男性更有可能从纳曲酮治疗饮酒中获益。
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