Traykov Latchezar, Bayle Anne Catherine, Latour Florence, Lenoir Hermine, Seux Marie-Laure, Hanon Olivier, Péquignot Renaud, Bert Pierre, Moulin Florence, Cantegreil Inge, Wenisch Emilie, Batouche Fériel, Mehrabian Shima, Rotrou Jocelyne de, Rigaud Anne-Sophie
Hôpital Broca, Paris, France.
J Neurol Sci. 2007 Jun 15;257(1-2):280-3. doi: 10.1016/j.jns.2007.01.038. Epub 2007 Mar 6.
Late-onset depression (LOD) could be a very early manifestation of Alzheimer's disease (AD), although contradictory results have been reported. Cerebrovascular disease (CVD) may favor the development of LOD, and that the particular forms of vascular depression should be individualized. The Apolipoprotein E (ApoE) epsilon4 allele was shown to be a risk factor for AD. Its role in LOD is controversial, while it is still unknown in vascular depression. Our objective was to clarify the relationship between ApoE epsilon4 allele and LOD in patients with and without CVD. We examined the ApoE phenotypes in a sample of 311 subjects: 50 with vascular LOD, 24 with LOD without CVD, 115 with AD and 122 normal controls (NC). The study of the ApoE epsilon4 allele frequency showed significant differences between: AD group and the vascular LOD and NC groups; LOD group without CVD compared with NC group (p<0.05 to 0.001). The frequency of the epsilon4 allele in the LOD group without CVD did not differ significantly from the AD group, similarly the frequency of the epsilon4 allele in the vascular LOD group was not different from that in NC. The study suggests an association between the ApoE epsilon4 allele and the LOD without CVD. These patients could be at risk of developing AD by an epsilon4-dependent pathway. In contrast, the results show no association between the presence of ApoE epsilon4 allele and vascular depression and provide further evidence in support of the concept that ApoE epsilon4 allele is not associated with clinical CVD.
迟发性抑郁症（LOD）可能是阿尔茨海默病（AD）的一种非常早期的表现，尽管已有相互矛盾的报道。脑血管疾病（CVD）可能有利于LOD的发展，并且血管性抑郁症的特定形式应个体化。载脂蛋白E（ApoE）ε4等位基因被证明是AD的一个危险因素。其在LOD中的作用存在争议，而在血管性抑郁症中的作用仍不清楚。我们的目的是阐明有无CVD的患者中ApoE ε4等位基因与LOD之间的关系。我们在311名受试者的样本中检测了ApoE表型：50例患有血管性LOD，24例患有无CVD的LOD，115例患有AD，122例为正常对照（NC）。对ApoE ε4等位基因频率的研究显示：AD组与血管性LOD组和NC组之间存在显著差异；无CVD的LOD组与NC组相比（p<0.05至0.001）。无CVD的LOD组中ε4等位基因的频率与AD组无显著差异，同样，血管性LOD组中ε4等位基因的频率与NC组也无差异。该研究表明ApoE ε4等位基因与无CVD的LOD之间存在关联。这些患者可能通过ε4依赖途径有患AD的风险。相比之下，结果显示ApoE ε4等位基因的存在与血管性抑郁症之间无关联，并进一步支持了ApoE ε4等位基因与临床CVD无关这一概念的证据。
