Gresner Peter, Gromadzinska Jolanta, Wasowicz Wojciech
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
Lung Cancer. 2007 Jul;57(1):1-25. doi: 10.1016/j.lungcan.2007.02.002. Epub 2007 Mar 6.
Available data indicate that there are significant differences in individual susceptibility to lung cancer within the human population. It is believed to be underlie by inherited genetic predispositions related to the genetic polymorphism of several enzymes involved in the detoxification and xenobiotic metabolism. In this review, we collect and discuss the evidence reported up to date on the association between lung cancer and genetic polymorphism of cytochromes P450, N-acetyltransferase, glutathione S-transferases, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, myeloperoxidase and glutathione peroxidase. All these genes might appear to be candidates for lung cancer susceptibility genes, nevertheless, the present state of the art still offers only a limited explanation of the link between such polymorphisms and increased risk of lung cancer.
现有数据表明，人群中个体对肺癌的易感性存在显著差异。人们认为这是由与几种参与解毒和外源性物质代谢的酶的基因多态性相关的遗传易感性所导致的。在本综述中，我们收集并讨论了迄今为止报道的关于肺癌与细胞色素P450、N - 乙酰转移酶、谷胱甘肽S - 转移酶、微粒体环氧化物水解酶、NAD(P)H：醌氧化还原酶、髓过氧化物酶和谷胱甘肽过氧化物酶基因多态性之间关联的证据。所有这些基因似乎都可能是肺癌易感基因的候选者，然而，目前的技术水平对这些多态性与肺癌风险增加之间的联系仍只能提供有限的解释。
