Ait Menguellet S, Collinet P, Cosson M, Mariette C, Triboulet J-P, Vinatier D
Clinique de gynécologie, hôpital Jeanne-de-Flandre, centre hospitalier régional universitaire (CHRU) de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
Gynecol Obstet Fertil. 2007 Apr;35(4):290-6. doi: 10.1016/j.gyobfe.2007.02.011. Epub 2007 Mar 6.
Adhesion barriers are intraperitoneal agents, solid or fluid, developed in order to prevent postoperative adhesions. In this article, we evaluate the efficiency of these new barrier agents for adhesion prevention in gynaecologic surgery, undertaking a review of controlled clinical trials published. Several human clinical trials demonstrated the safety and efficiency of both Interceed and Seprafilm. As far as other barrier agents are concerned, data are still insufficient to recommend them for clinical use. There is a need for other randomised controlled trials in order to evaluate functional efficiency of anti adhesion agents.
粘连屏障剂是为防止术后粘连而研发的腹腔内用药，有固体或液体剂型。在本文中，我们通过回顾已发表的对照临床试验，评估了这些新型屏障剂在妇科手术中预防粘连的效果。多项人体临床试验证明了Interceed和Seprafilm的安全性和有效性。至于其他屏障剂，现有数据仍不足以推荐其用于临床。需要开展其他随机对照试验来评估抗粘连剂的功能效果。
