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六味地黄丸水煎剂对快速老化小鼠海马基因表达的影响。

The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.

作者信息

Cheng Xiao-Rui, Zhou Wen-Xia, Zhang Yong-Xiang

机构信息

Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.

出版信息

Fitoterapia. 2007 Apr;78(3):175-81. doi: 10.1016/j.fitote.2006.11.006. Epub 2007 Feb 6.

DOI:10.1016/j.fitote.2006.11.006
PMID:17337329
Abstract

Liuwei Dihuang decoction (LW), a traditional Chinese medicinal prescription, enhances the cognitive function of CNS by significant modulating effects on some of the gene expressions. Expressions of genes, such as DUSP12, NSF, STUB1, CaMKIIalpha, AMFR, UQCRFS1 and other 11 novel genes without any functional clues changed significantly. These genes are involved in the protein-tyrosine phosphatase family, the AAA (ATPases associated with diverse cellular activities) gene family, the serine/threonine protein kinases family, ubiquitin ligase, mitochondrial function and so on.

摘要

六味地黄丸（LW）是一种传统中药方剂，通过对某些基因表达的显著调节作用来增强中枢神经系统的认知功能。双特异性磷酸酶12（DUSP12）、N-乙基马来酰胺敏感因子（NSF）、Stub1蛋白（STUB1）、α-钙调蛋白依赖性蛋白激酶（CaMKIIalpha）、自噬膜相关蛋白（AMFR）、泛醌细胞色素c还原酶核心蛋白1（UQCRFS1）等基因以及其他11个无任何功能线索的新基因的表达发生了显著变化。这些基因涉及蛋白质酪氨酸磷酸酶家族、AAA（与多种细胞活动相关的ATP酶）基因家族、丝氨酸/苏氨酸蛋白激酶家族、泛素连接酶、线粒体功能等。

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