Yasmin Farzana, Haleem Darakhshan J, Haleem M A
Department of Biomedical Engineering, NED University of Engineering and Technology, Karachi, Pakistan.
Pak J Pharm Sci. 2007 Jan;20(1):51-5.
The present study was designed to evaluate the effects of simultaneous ethanol administration (10%, v/v), and restraint stress (2 hrs/day for 5 day) on serum electrolytes. This restraint stress decreases serum concentration of Na(+), K(+), Ca(2+), phosphorus, and chloride. Ethanol treatment also decreased Na(+), K(+), Ca(2+), phosphorus, and chloride concentration. The decrease in Ca(2+) and phosphorus levels was greater for ethanol-treated restrained than water-treated restrained rats. Ethanol did not affect serum Mg(2+) while it was increased in restrained water-treated rats. Ethanol-treated restrained rats exhibited less serum Mg(2+) than ethanol-treated unrestrained or water-treated restrained rats. Possible mechanism involved in restraint or ethanol-induced changes of electrolytes is discussed. In conclusion, the result of this study suggest that alteration of serum electrolyte caused by repeated restrained in water-treated and ethanol-treated rats could possibly occur due to an increase in sympathetic activity leading to enhanced excretion of these electrolytes.
本研究旨在评估同时给予乙醇（10%，v/v）和束缚应激（每天2小时，持续5天）对血清电解质的影响。这种束缚应激会降低血清中钠（+）、钾（+）、钙（2+）、磷和氯的浓度。乙醇处理也会降低钠（+）、钾（+）、钙（2+）、磷和氯的浓度。与给予水的束缚大鼠相比，给予乙醇的束缚大鼠钙（2+）和磷水平的降低幅度更大。乙醇对血清镁（2+）没有影响，而在给予水的束缚大鼠中血清镁（2+）会升高。给予乙醇的束缚大鼠的血清镁（2+）水平低于给予乙醇的非束缚大鼠或给予水的束缚大鼠。文中讨论了束缚或乙醇诱导电解质变化可能涉及的机制。总之，本研究结果表明，在给予水和给予乙醇的大鼠中，反复束缚引起的血清电解质改变可能是由于交感神经活动增加导致这些电解质排泄增强所致。
